diff --git a/pkgs/development/libraries/libtiff/default.nix b/pkgs/development/libraries/libtiff/default.nix
index 15ed6b6ed18..2fad2988898 100644
--- a/pkgs/development/libraries/libtiff/default.nix
+++ b/pkgs/development/libraries/libtiff/default.nix
@@ -18,6 +18,10 @@ stdenv.mkDerivation rec {
     sha256 = "0d46bdvxdiv59lxnb0xz9ywm8arsr6xsapi5s6y6vnys2wjz6aax";
   };
 
+  cmakeFlags = if stdenv.isDarwin then [
+    "-DCMAKE_SKIP_BUILD_RPATH=OFF"
+  ] else null;
+
   # FreeImage needs this patch
   patches = [ ./headers.patch ];